MRGPRX2-Mediated Degranulation of Human Skin Mast Cells Requires the Operation of G(αi), G(αq), Ca++ Channels, ERK1/2 and PI3K—Interconnection between Early and Late Signaling

The recent discovery of MRGPRX2 explains mast cell (MC)-dependent symptoms independently of FcεRI-activation. Because of its novelty, signaling cascades triggered by MRGPRX2 are rudimentarily understood, especially in cutaneous MCs, by which MRGPRX2 is chiefly expressed. Here, MCs purified from huma...

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Detalles Bibliográficos
Autores principales: Wang, Zhao, Franke, Kristin, Bal, Gürkan, Li, Zhuoran, Zuberbier, Torsten, Babina, Magda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946553/
https://www.ncbi.nlm.nih.gov/pubmed/35326404
http://dx.doi.org/10.3390/cells11060953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946553/
https://www.ncbi.nlm.nih.gov/pubmed/35326404
http://dx.doi.org/10.3390/cells11060953

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