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MRGPRX2-Mediated Degranulation of Human Skin Mast Cells Requires the Operation of G(αi), G(αq), Ca++ Channels, ERK1/2 and PI3K—Interconnection between Early and Late Signaling
The recent discovery of MRGPRX2 explains mast cell (MC)-dependent symptoms independently of FcεRI-activation. Because of its novelty, signaling cascades triggered by MRGPRX2 are rudimentarily understood, especially in cutaneous MCs, by which MRGPRX2 is chiefly expressed. Here, MCs purified from huma...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946553/ https://www.ncbi.nlm.nih.gov/pubmed/35326404 http://dx.doi.org/10.3390/cells11060953 |