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The Clinical Concept of LTDpathy: Is Dysregulated LTD Responsible for Prodromal Cerebellar Symptoms?

Long-term depression at parallel fibers-Purkinje cells (PF-PC LTD) is essential for cerebellar motor learning and motor control. Recent progress in ataxiology has identified dysregulation of PF-PC LTD in the pathophysiology of certain types of immune-mediated cerebellar ataxias (IMCAs). Auto-antibod...

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Detalles Bibliográficos
Autores principales: Mitoma, Hiroshi, Yamaguchi, Kazuhiko, Honnorat, Jerome, Manto, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946597/
https://www.ncbi.nlm.nih.gov/pubmed/35326260
http://dx.doi.org/10.3390/brainsci12030303