Synergy of Venetoclax and 8-Chloro-Adenosine in AML: The Interplay of rRNA Inhibition and Fatty Acid Metabolism

SIMPLE SUMMARY: Treatment failures of acute myeloid leukemia (AML) have been attributed to the persistence of leukemia stem cells (LSCs), which are refractory to conventional treatments. Venetoclax (VEN), currently FDA-approved in combination with low-dose cytarabine or hypomethylating agents, is hi...

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Detalles Bibliográficos
Autores principales: Hoang, Dinh Hoa, Morales, Corey, Rodriguez, Ivan Rodriguez, Valerio, Melissa, Guo, Jiamin, Chen, Min-Hsuan, Wu, Xiwei, Horne, David, Gandhi, Varsha, Chen, Lisa S., Zhang, Bin, Pullarkat, Vinod, Rosen, Steven T., Marcucci, Guido, Buettner, Ralf, Nguyen, Le Xuan Truong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946614/
https://www.ncbi.nlm.nih.gov/pubmed/35326597
http://dx.doi.org/10.3390/cancers14061446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946614/
https://www.ncbi.nlm.nih.gov/pubmed/35326597
http://dx.doi.org/10.3390/cancers14061446

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