Cargando…
Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo
Parkinson’s disease (PD) is associated with motor and non-motor symptoms and characterized by aggregates of alpha-synuclein (αSyn). Naturally occurring antibodies (nAbs) are part of the innate immune system, produced without prior contact to their specific antigen, and polyreactive. The abundance of...
Autores principales: | Braczynski, Anne K., Sevenich, Marc, Gering, Ian, Kupreichyk, Tatsiana, Agerschou, Emil D., Kronimus, Yannick, Habib, Pardes, Stoldt, Matthias, Willbold, Dieter, Schulz, Jörg B., Bach, Jan-Philipp, Falkenburger, Björn H., Hoyer, Wolfgang |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946620/ https://www.ncbi.nlm.nih.gov/pubmed/35327661 http://dx.doi.org/10.3390/biom12030469 |
Ejemplares similares
-
Nucleation of α-Synuclein Amyloid Fibrils Induced by Cross-Interaction with β-Hairpin Peptides Derived from Immunoglobulin Light Chains
por: Heid, Laetitia F., et al.
Publicado: (2023) -
Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth
por: Wördehoff, Michael M., et al.
Publicado: (2017) -
An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils
por: Agerschou, Emil Dandanell, et al.
Publicado: (2019) -
Inhibitor and substrate cooperate to inhibit amyloid fibril elongation of α-synuclein
por: Agerschou, Emil Dandanell, et al.
Publicado: (2020) -
Extending the functional characteristics of naturally occurring autoantibodies against β-Amyloid, Prion Protein and α-Synuclein
por: Albus, Alexandra, et al.
Publicado: (2018)