Addressing the Elephant in the Immunotherapy Room: Effector T-Cell Priming versus Depletion of Regulatory T-Cells by Anti-CTLA-4 Therapy

SIMPLE SUMMARY: Immunotherapy has transformed the treatment of advanced cancers by leveraging patients’ immune system in attacking tumor cells. Cytotoxic T-lymphocyte Associated Protein 4 (CTLA-4) is an immune checkpoint molecule highly expressed on regulatory T-cells (Tregs) that suppresses the fun...

Descripción completa

Detalles Bibliográficos
Autores principales: Hong, Megan M Y, Maleki Vareki, Saman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946681/
https://www.ncbi.nlm.nih.gov/pubmed/35326731
http://dx.doi.org/10.3390/cancers14061580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946681/
https://www.ncbi.nlm.nih.gov/pubmed/35326731
http://dx.doi.org/10.3390/cancers14061580

Ejemplares similares