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Addressing the Elephant in the Immunotherapy Room: Effector T-Cell Priming versus Depletion of Regulatory T-Cells by Anti-CTLA-4 Therapy

SIMPLE SUMMARY: Immunotherapy has transformed the treatment of advanced cancers by leveraging patients’ immune system in attacking tumor cells. Cytotoxic T-lymphocyte Associated Protein 4 (CTLA-4) is an immune checkpoint molecule highly expressed on regulatory T-cells (Tregs) that suppresses the fun...

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Detalles Bibliográficos
Autores principales:	Hong, Megan M Y, Maleki Vareki, Saman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946681/ https://www.ncbi.nlm.nih.gov/pubmed/35326731 http://dx.doi.org/10.3390/cancers14061580

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