Significant sparse polygenic risk scores across 813 traits in UK Biobank

We present a systematic assessment of polygenic risk score (PRS) prediction across more than 1,500 traits using genetic and phenotype data in the UK Biobank. We report 813 sparse PRS models with significant (p < 2.5 x 10(−5)) incremental predictive performance when compared against the covariate-...

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Detalles Bibliográficos
Autores principales: Tanigawa, Yosuke, Qian, Junyang, Venkataraman, Guhan, Justesen, Johanne Marie, Li, Ruilin, Tibshirani, Robert, Hastie, Trevor, Rivas, Manuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946745/
https://www.ncbi.nlm.nih.gov/pubmed/35324888
http://dx.doi.org/10.1371/journal.pgen.1010105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946745/
https://www.ncbi.nlm.nih.gov/pubmed/35324888
http://dx.doi.org/10.1371/journal.pgen.1010105

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