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Kv7 Channels in Cyclic-Nucleotide Dependent Relaxation of Rat Intra-Pulmonary Artery

Pulmonary hypertension is treated with drugs that stimulate cGMP or cAMP signalling. Both nucleotides can activate Kv7 channels, leading to smooth muscle hyperpolarisation, reduced Ca(2+) influx and relaxation. Kv7 activation by cGMP contributes to the pulmonary vasodilator action of nitric oxide, b...

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Detalles Bibliográficos
Autores principales:	Al-Chawishly, Mohammed, Loveland, Oliver, Gurney, Alison M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946781/ https://www.ncbi.nlm.nih.gov/pubmed/35327621 http://dx.doi.org/10.3390/biom12030429

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