A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

The Leucine Rich Repeat Kinase 2 (LRRK2) gene is a major genetic determinant of Parkinson’s disease (PD), encoding a homonymous multi-domain protein with two catalytic activities, GTPase and Kinase, involved in intracellular signaling and trafficking. LRRK2 is phosphorylated at multiple sites, inclu...

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Detalles Bibliográficos
Autores principales: Marchand, Antoine, Sarchione, Alessia, Athanasopoulos, Panagiotis S., Roy, Hélène Bauderlique-Le, Goveas, Liesel, Magnez, Romain, Drouyer, Matthieu, Emanuele, Marco, Ho, Franz Y., Liberelle, Maxime, Melnyk, Patricia, Lebègue, Nicolas, Thuru, Xavier, Nichols, R. Jeremy, Greggio, Elisa, Kortholt, Arjan, Galli, Thierry, Chartier-Harlin, Marie-Christine, Taymans, Jean-Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946913/
https://www.ncbi.nlm.nih.gov/pubmed/35326469
http://dx.doi.org/10.3390/cells11061018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946913/
https://www.ncbi.nlm.nih.gov/pubmed/35326469
http://dx.doi.org/10.3390/cells11061018

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