Cargando…

Fingolimod (FTY720), a Sphinogosine-1-Phosphate Receptor Agonist, Mitigates Choroidal Endothelial Proangiogenic Properties and Choroidal Neovascularization

Neovascular or wet age-related macular degeneration (nAMD) causes vision loss due to inflammatory and vascular endothelial growth factor (VEGF)-driven neovascularization processes in the choroid. Due to the excess in VEGF levels associated with nAMD, anti-VEGF therapies are utilized for treatment. U...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sorenson, Christine M., Farnoodian, Mitra, Wang, Shoujian, Song, Yong-Seok, Darjatmoko, Soesiawati R., Polans, Arthur S., Sheibani, Nader
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946992/ https://www.ncbi.nlm.nih.gov/pubmed/35326420 http://dx.doi.org/10.3390/cells11060969

Ejemplares similares

Bim Expression Promotes the Clearance of Mononuclear Phagocytes during Choroidal Neovascularization, Mitigating Scar Formation in Mice
por: Wang, Shoujian, et al.
Publicado: (2022)

The Sustained Delivery of Resveratrol or a Defined Grape Powder Inhibits New Blood Vessel Formation in a Mouse Model of Choroidal Neovascularization
por: Kanavi, Mozhgan Rezaie, et al.
Publicado: (2014)

Caffeine Inhibits Choroidal Neovascularization Through Mitigation of Inflammatory and Angiogenesis Activities
por: Sorenson, Christine M., et al.
Publicado: (2021)

Targeted Thrombospondin-1 Expression in Ocular Vascular Development and Neovascularization
por: Sorenson, Christine M., et al.
Publicado: (2021)

Vitamin D receptor expression is essential during retinal vascular development and attenuation of neovascularization by 1, 25(OH)(2)D(3)
por: Jamali, Nasim, et al.
Publicado: (2017)

Expression of Thrombospondin-1 Modulates the Angioinflammatory Phenotype of Choroidal Endothelial Cells
por: Fei, Ping, et al.
Publicado: (2014)

β2–Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression
por: Lavine, Jeremy A., et al.
Publicado: (2017)

The antineoplastic properties of FTY720: evidence for the repurposing of fingolimod
por: Patmanathan, Sathya Narayanan, et al.
Publicado: (2015)

The emerging role of FTY720 (Fingolimod) in cancer treatment
por: White, Christopher, et al.
Publicado: (2016)

Fingolimod (Gileyna, FTY720): Innovative treatment for multiple sclerosis
por: Pinki,, et al.
Publicado: (2011)

Fingolimod (FTY720): First approved oral therapy for multiple sclerosis
por: Sharma, Sushil, et al.
Publicado: (2011)

The Immunosuppressant FTY720 (Fingolimod) enhances Glycosaminoglycan depletion in articular cartilage
por: Stradner, Martin H, et al.
Publicado: (2011)

FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination
por: Blanc, Caroline A, et al.
Publicado: (2014)

Protective role of fingolimod (FTY720) in rats subjected to subarachnoid hemorrhage
por: Xu, Hao-Liang, et al.
Publicado: (2015)

Cytochrome P450 1B1 Expression Regulates Intracellular Iron Levels and Oxidative Stress in the Retinal Endothelium
por: Song, Yong-Seok, et al.
Publicado: (2023)

Fingolimod (FTY720) Stimulates Ca(2+)/Calcineurin Signaling in Fission Yeast
por: Hagihara, Kanako, et al.
Publicado: (2013)

FTY720 (Fingolimod) sensitizes hepatocellular carcinoma cells to sorafenib-mediated cytotoxicity
por: Ahmed, Dilruba, et al.
Publicado: (2015)

The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars
por: Aoki, Masayo, et al.
Publicado: (2020)

Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy
por: Enoru, Julius O., et al.
Publicado: (2016)

Placental Growth Factor Inhibition for Choroidal Neovascularization
por: Sheibani, Nader
Publicado: (2013)

Effect of FTY720 (fingolimod) on graft survival in renal transplant recipients: a systematic review protocol
por: Gholamnezhadjafari, Reza, et al.
Publicado: (2016)

FTY720-derivatives do not induce FTY720-like lymphopenia
por: Segura-Ulate, Ismael, et al.
Publicado: (2017)

CD11c(+) macrophages are proangiogenic and necessary for experimental choroidal neovascularization
por: Droho, Steven, et al.
Publicado: (2023)

FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons
por: Takasugi, Nobumasa, et al.
Publicado: (2013)

Acute Anterior Uveitis in a Patient Taking Fingolimod (FTY720) for Multiple Sclerosis
por: Mack, Heather Gwen, et al.
Publicado: (2016)

Bim Expression Modulates Branching Morphogenesis of the Epithelium and Endothelium
por: Sorenson, Christine M., et al.
Publicado: (2022)

Effects of FTY720 (Fingolimod) on Proliferation, Differentiation, and Migration of Brain-Derived Neural Stem Cells
por: Tan, Botao, et al.
Publicado: (2016)

Characterization of the effects of immunomodulatory drug fingolimod (FTY720) on human T cell receptor signaling pathways
por: Baer, Alan, et al.
Publicado: (2018)

Fingolimod (FTY720) improves postoperative cognitive dysfunction in mice subjected to D-galactose-induced aging
por: Zhang, Jie, et al.
Publicado: (2020)

Adenosine Receptors Expression in Human Retina and Choroid with Age-related Macular Degeneration
por: Goebel, Collin P., et al.
Publicado: (2023)

Fingolimod (FTY720-P) Does Not Stabilize the Blood–Brain Barrier under Inflammatory Conditions in an in Vitro Model
por: Schuhmann, Michael K., et al.
Publicado: (2015)

Modulatory Effects of Fingolimod (FTY720) on the Expression of Sphingolipid Metabolism-Related Genes in an Animal Model of Alzheimer’s Disease
por: Jęśko, Henryk, et al.
Publicado: (2018)

Fingolimod (FTY720) Preserves High Energy Phosphates and Improves Cardiac Function in Heterotopic Heart Transplantation Model
por: Ahmed, Naseer, et al.
Publicado: (2020)

FTY720 (Fingolimod) Ameliorates Brain Injury through Multiple Mechanisms and is a Strong Candidate for Stroke Treatment
por: Wang, Zifeng, et al.
Publicado: (2020)

FTY720 attenuates excitotoxicity and neuroinflammation
por: Cipriani, Raffaela, et al.
Publicado: (2015)

Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) Attenuates Myocardial Fibrosis in Post-heterotopic Heart Transplantation
por: Ahmed, Naseer, et al.
Publicado: (2017)

Ameliorative effects of Fingolimod (FTY720) on microglial activation and psychosis-related behavior in short term cuprizone exposed mice
por: Li, Siyao, et al.
Publicado: (2023)

Negative Regulators of Angiogenesis, Ocular Vascular Homeostasis, and Pathogenesis and Treatment of Exudative AMD
por: Farnoodian, Mitra, et al.
Publicado: (2018)

Spectral domain-optical coherence tomography retinal biomarkers in choroidal neovascularization of multifocal choroiditis, myopic choroidal neovascularization, and idiopathic choroidal neovascularization
por: Gao, Rui, et al.
Publicado: (2021)

New FTY720-docetaxel nanoparticle therapy overcomes FTY720-induced lymphopenia and inhibits metastatic breast tumour growth
por: Alshaker, Heba, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_omn39iemtj1hscfa658ra5a3o4