Induction of mismatch repair deficiency, compromised DNA damage signaling and compound hypermutagenesis by a dietary mutagen in a cell-based model for Lynch syndrome

The prevalent cancer predisposition Lynch syndrome (LS, OMIM #120435) is caused by an inherited heterozygous defect in any of the four core DNA mismatch repair (MMR) genes MSH2, MSH6, MLH1 or PMS2. MMR repairs errors by the replicative DNA polymerases in all proliferating tissues. Its deficiency, fo...

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Detalles Bibliográficos
Autores principales: Ijsselsteijn, Robbert, van Hees, Sandrine, Drost, Mark, Jansen, Jacob G, de Wind, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Carcinogenesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947211/
https://www.ncbi.nlm.nih.gov/pubmed/34919656
http://dx.doi.org/10.1093/carcin/bgab108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947211/
https://www.ncbi.nlm.nih.gov/pubmed/34919656
http://dx.doi.org/10.1093/carcin/bgab108

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