Caenorhabditis elegans provides an efficient drug screening platform for GNAO1-related disorders and highlights the potential role of caffeine in controlling dyskinesia

Dominant GNAO1 mutations cause an emerging group of childhood-onset neurological disorders characterized by developmental delay, intellectual disability, movement disorders, drug-resistant seizures and neurological deterioration. GNAO1 encodes the α-subunit of an inhibitory GTP/GDP-binding protein r...

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Detalles Bibliográficos
Autores principales: Di Rocco, Martina, Galosi, Serena, Lanza, Enrico, Tosato, Federica, Caprini, Davide, Folli, Viola, Friedman, Jennifer, Bocchinfuso, Gianfranco, Martire, Alberto, Di Schiavi, Elia, Leuzzi, Vincenzo, Martinelli, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947233/
https://www.ncbi.nlm.nih.gov/pubmed/34622282
http://dx.doi.org/10.1093/hmg/ddab296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947233/
https://www.ncbi.nlm.nih.gov/pubmed/34622282
http://dx.doi.org/10.1093/hmg/ddab296

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