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Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28

Proviral integration sites for Moloney murine leukemia virus (PIM) kinases are upregulated at the protein level in response to hypoxia and have multiple protumorigenic functions, promoting cell growth, survival, and angiogenesis. However, the mechanism responsible for the induction of PIM in hypoxia...

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Detalles Bibliográficos
Autores principales: Toth, Rachel K., Solomon, Regina, Warfel, Noel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947361/
https://www.ncbi.nlm.nih.gov/pubmed/35326457
http://dx.doi.org/10.3390/cells11061006