Elevated ATP via enhanced miRNA-30b, 30c, and 30e downregulates the expression of CD73 in CD8(+) T cells of HIV-infected individuals

CD8(+) T cells play a crucial role against chronic viral infections, however, their effector functions are influenced by the expression of co-stimulatory/inhibitory receptors. For example, CD73 works with CD39 to convert highly inflammatory ATP to adenosine. However, its expression on T cells in the...

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Detalles Bibliográficos
Autores principales: Shahbaz, Shima, Okoye, Isobel, Blevins, Gregg, Elahi, Shokrollah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947394/
https://www.ncbi.nlm.nih.gov/pubmed/35325005
http://dx.doi.org/10.1371/journal.ppat.1010378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947394/
https://www.ncbi.nlm.nih.gov/pubmed/35325005
http://dx.doi.org/10.1371/journal.ppat.1010378

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