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Elevated ATP via enhanced miRNA-30b, 30c, and 30e downregulates the expression of CD73 in CD8(+) T cells of HIV-infected individuals
CD8(+) T cells play a crucial role against chronic viral infections, however, their effector functions are influenced by the expression of co-stimulatory/inhibitory receptors. For example, CD73 works with CD39 to convert highly inflammatory ATP to adenosine. However, its expression on T cells in the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947394/ https://www.ncbi.nlm.nih.gov/pubmed/35325005 http://dx.doi.org/10.1371/journal.ppat.1010378 |