Isotope-assisted metabolic flux analysis as an equality-constrained nonlinear program for improved scalability and robustness

Stable isotope-assisted metabolic flux analysis (MFA) is a powerful method to estimate carbon flow and partitioning in metabolic networks. At its core, MFA is a parameter estimation problem wherein the fluxes and metabolite pool sizes are model parameters that are estimated, via optimization, to acc...

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Detalles Bibliográficos
Autores principales: Lugar, Daniel J., Sriram, Ganesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947808/
https://www.ncbi.nlm.nih.gov/pubmed/35324890
http://dx.doi.org/10.1371/journal.pcbi.1009831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947808/
https://www.ncbi.nlm.nih.gov/pubmed/35324890
http://dx.doi.org/10.1371/journal.pcbi.1009831

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