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Isotope-assisted metabolic flux analysis as an equality-constrained nonlinear program for improved scalability and robustness
Stable isotope-assisted metabolic flux analysis (MFA) is a powerful method to estimate carbon flow and partitioning in metabolic networks. At its core, MFA is a parameter estimation problem wherein the fluxes and metabolite pool sizes are model parameters that are estimated, via optimization, to acc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947808/ https://www.ncbi.nlm.nih.gov/pubmed/35324890 http://dx.doi.org/10.1371/journal.pcbi.1009831 |