Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with bivalent interaction

Understanding the underlying molecular mechanisms behind ADE of SARS-CoV-2 is critical for development of safe and effective therapies. Here, we report that two neutralizing mAbs, MW01 and MW05, could enhance the infection of SARS-CoV-2 pseudovirus on FcγRIIB-expressing B cells. X-ray crystal struct...

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Detalles Bibliográficos
Autores principales: Wang, Shuang, Wang, Junchao, Yu, Xiaojuan, Jiang, Wen, Chen, Shuo, Wang, Rongjuan, Wang, Mingzhu, Jiao, Shasha, Yang, Yingying, Wang, Wenbo, Chen, Huilin, Chen, Ben, Gu, Chunying, Liu, Chuang, Wang, An, Wang, Min, Li, Gang, Guo, Cuicui, Liu, Datao, Zhang, Jinchao, Zhang, Min, Wang, Lan, Gui, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948278/
https://www.ncbi.nlm.nih.gov/pubmed/35332252
http://dx.doi.org/10.1038/s42003-022-03207-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948278/
https://www.ncbi.nlm.nih.gov/pubmed/35332252
http://dx.doi.org/10.1038/s42003-022-03207-0

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