Identification of the toxic 6mer seed consensus for human cancer cells

6mer seed toxicity is a novel cell death mechanism that kills cancer cells by triggering death induced by survival gene elimination (DISE). It is based on si- or shRNAs with a specific G-rich nucleotide composition in position 2–7 of their guide strand. An arrayed screen of 4096 6mer seeds on two hu...

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Detalles Bibliográficos
Autores principales: Patel, Monal, Bartom, Elizabeth T., Paudel, Bidur, Kocherginsky, Masha, O’Shea, Kaitlyn L., Murmann, Andrea E., Peter, Marcus E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948288/
https://www.ncbi.nlm.nih.gov/pubmed/35332222
http://dx.doi.org/10.1038/s41598-022-09051-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948288/
https://www.ncbi.nlm.nih.gov/pubmed/35332222
http://dx.doi.org/10.1038/s41598-022-09051-w

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