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Colorectal Cancer‐Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD‐L1 Expression in Tumor‐Associated Macrophages (Adv. Sci. 9/2022)
Small Extracellular Vesicles In colorectal cancer (CRC) tissues, tumor cell‐derived small extracellular vesicles (sEVs) miR‐21‐5p and miR‐200a synergistically induce macrophage M2 like polarization and PD‐L1 expression by regulating the PTEN/AKT and SCOS1/STAT1 pathways, resulting in decreased CD8(+...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948544/ http://dx.doi.org/10.1002/advs.202270057 |
| _version_ | 1784674678096265216 |
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| author | Yin, Yuan Liu, Bingxin Cao, Yulin Yao, Surui Liu, Yuhang Jin, Guoying Qin, Yan Chen, Ying Cui, Kaisa Zhou, Leyuan Bian, Zehua Fei, Bojian Huang, Shenglin Huang, Zhaohui |
| author_facet | Yin, Yuan Liu, Bingxin Cao, Yulin Yao, Surui Liu, Yuhang Jin, Guoying Qin, Yan Chen, Ying Cui, Kaisa Zhou, Leyuan Bian, Zehua Fei, Bojian Huang, Shenglin Huang, Zhaohui |
| author_sort | Yin, Yuan |
| collection | PubMed |
| description | Small Extracellular Vesicles In colorectal cancer (CRC) tissues, tumor cell‐derived small extracellular vesicles (sEVs) miR‐21‐5p and miR‐200a synergistically induce macrophage M2 like polarization and PD‐L1 expression by regulating the PTEN/AKT and SCOS1/STAT1 pathways, resulting in decreased CD8(+) T cell activity and increased tumor growth. More details can be found in article number 202102620 by Shenglin Huang, Zhaohui Huang, and co‐workers. [Image: see text] |
| format | Online Article Text |
| id | pubmed-8948544 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-89485442022-03-29 Colorectal Cancer‐Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD‐L1 Expression in Tumor‐Associated Macrophages (Adv. Sci. 9/2022) Yin, Yuan Liu, Bingxin Cao, Yulin Yao, Surui Liu, Yuhang Jin, Guoying Qin, Yan Chen, Ying Cui, Kaisa Zhou, Leyuan Bian, Zehua Fei, Bojian Huang, Shenglin Huang, Zhaohui Adv Sci (Weinh) Inside Back Cover Small Extracellular Vesicles In colorectal cancer (CRC) tissues, tumor cell‐derived small extracellular vesicles (sEVs) miR‐21‐5p and miR‐200a synergistically induce macrophage M2 like polarization and PD‐L1 expression by regulating the PTEN/AKT and SCOS1/STAT1 pathways, resulting in decreased CD8(+) T cell activity and increased tumor growth. More details can be found in article number 202102620 by Shenglin Huang, Zhaohui Huang, and co‐workers. [Image: see text] John Wiley and Sons Inc. 2022-03-25 /pmc/articles/PMC8948544/ http://dx.doi.org/10.1002/advs.202270057 Text en © 2022 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Inside Back Cover Yin, Yuan Liu, Bingxin Cao, Yulin Yao, Surui Liu, Yuhang Jin, Guoying Qin, Yan Chen, Ying Cui, Kaisa Zhou, Leyuan Bian, Zehua Fei, Bojian Huang, Shenglin Huang, Zhaohui Colorectal Cancer‐Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD‐L1 Expression in Tumor‐Associated Macrophages (Adv. Sci. 9/2022) |
| title | Colorectal Cancer‐Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD‐L1 Expression in Tumor‐Associated Macrophages (Adv. Sci. 9/2022) |
| title_full | Colorectal Cancer‐Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD‐L1 Expression in Tumor‐Associated Macrophages (Adv. Sci. 9/2022) |
| title_fullStr | Colorectal Cancer‐Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD‐L1 Expression in Tumor‐Associated Macrophages (Adv. Sci. 9/2022) |
| title_full_unstemmed | Colorectal Cancer‐Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD‐L1 Expression in Tumor‐Associated Macrophages (Adv. Sci. 9/2022) |
| title_short | Colorectal Cancer‐Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD‐L1 Expression in Tumor‐Associated Macrophages (Adv. Sci. 9/2022) |
| title_sort | colorectal cancer‐derived small extracellular vesicles promote tumor immune evasion by upregulating pd‐l1 expression in tumor‐associated macrophages (adv. sci. 9/2022) |
| topic | Inside Back Cover |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948544/ http://dx.doi.org/10.1002/advs.202270057 |
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