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The Inhibition of the Small-Conductance Ca(2+)-Activated Potassium Channels Decreases the Sinus Node Pacemaking during Beta-Adrenergic Activation

Sinus pacemaking is based on tight cooperation of intracellular Ca(2+) handling and surface membrane ion channels. An important player of this synergistic crosstalk could be the small-conductance Ca(2+)-activated K(+)-channel (I(SK)) that could contribute to the sinoatrial node (SAN) pacemaking driv...

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Detalles Bibliográficos
Autores principales: Bitay, Gergő, Tóth, Noémi, Déri, Szilvia, Szlovák, Jozefina, Kohajda, Zsófia, Varró, András, Nagy, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948633/
https://www.ncbi.nlm.nih.gov/pubmed/35337111
http://dx.doi.org/10.3390/ph15030313