A Potent Inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator Blocks Disease and Morbidity Due to Toxigenic Vibrio cholerae

Vibrio cholerae uses cholera toxin (CT) to cause cholera, a severe diarrheal disease in humans that can lead to death within hours of the onset of symptoms. The catalytic activity of CT in target epithelial cells increases cellular levels of 3′,5′-cyclic AMP (cAMP), leading to the activation of the...

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Detalles Bibliográficos
Autores principales: Rivera-Chávez, Fabian, Meader, Bradley T., Akosman, Sinan, Koprivica, Vuk, Mekalanos, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948642/
https://www.ncbi.nlm.nih.gov/pubmed/35324722
http://dx.doi.org/10.3390/toxins14030225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948642/
https://www.ncbi.nlm.nih.gov/pubmed/35324722
http://dx.doi.org/10.3390/toxins14030225

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