Gene Expression Profiling and Protein Analysis Reveal Suppression of the C-Myc Oncogene and Inhibition JAK/STAT and PI3K/AKT/mTOR Signaling by Thymoquinone in Acute Myeloid Leukemia Cells

Overexpression of c-Myc plays an essential role in leukemogenesis and drug resistance, making c-Myc an attractive target for cancer therapy. However, targeting c-Myc directly is impossible, and c-Myc upstream regulator pathways could be targeted instead. This study investigated the effects of thymoq...

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Detalles Bibliográficos
Autores principales: Almajali, Belal, Johan, Muhammad Farid, Al-Wajeeh, Abdullah Saleh, Wan Taib, Wan Rohani, Ismail, Imilia, Alhawamdeh, Maysa, Al-Tawarah, Nafe M., Ibrahim, Wisam Nabeel, Al-Rawashde, Futoon Abedrabbu, Al-Jamal, Hamid Ali Nagi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948818/
https://www.ncbi.nlm.nih.gov/pubmed/35337104
http://dx.doi.org/10.3390/ph15030307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948818/
https://www.ncbi.nlm.nih.gov/pubmed/35337104
http://dx.doi.org/10.3390/ph15030307

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