Structure–Activity Relationship of N-Phenylthieno[2,3-b]pyridine-2-carboxamide Derivatives Designed as Forkhead Box M1 Inhibitors: The Effect of Electron-Withdrawing and Donating Substituents on the Phenyl Ring

We report synthesis, characterization, biological evaluation, and molecular-docking studies of 18 thieno[2,3-b]pyridines with a phenylacetamide moiety at position 2, which is disubstituted with F, Cl, Br, or I at position 4, and with electron-withdrawing and electron-donating groups (-CN, -NO(2), -C...

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Detalles Bibliográficos
Autores principales: Huerta-García, César Sebastian, Pérez, David J., Velázquez-Martínez, Carlos A., Tabatabaei Dakhili, Seyed Amirhossein, Romo-Mancillas, Antonio, Castillo, Rafael, Hernández-Campos, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949145/
https://www.ncbi.nlm.nih.gov/pubmed/35337081
http://dx.doi.org/10.3390/ph15030283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949145/
https://www.ncbi.nlm.nih.gov/pubmed/35337081
http://dx.doi.org/10.3390/ph15030283

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