The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Ameliorates Endothelial Inflammation and Microvascular Thrombosis in a Sepsis Mouse Model

The pathophysiology of sepsis involves inflammation and hypercoagulability, which lead to microvascular thrombosis and compromised organ perfusion. Dipeptidyl peptidase (DPP)-4 inhibitors, e.g., linagliptin, are commonly used anti-diabetic drugs known to exert anti-inflammatory effects. However, whe...

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Detalles Bibliográficos
Autores principales: Wang, Shen-Chih, Wang, Xiang-Yu, Liu, Chung-Te, Chou, Ruey-Hsing, Chen, Zhen Bouman, Huang, Po-Hsun, Lin, Shing-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949150/
https://www.ncbi.nlm.nih.gov/pubmed/35328486
http://dx.doi.org/10.3390/ijms23063065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949150/
https://www.ncbi.nlm.nih.gov/pubmed/35328486
http://dx.doi.org/10.3390/ijms23063065

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