Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2

Targeted drug conjugates based on Affibody molecules fused to an albumin-binding domain (ABD) for half-life extension have demonstrated potent anti-tumor activity in preclinical therapeutic studies. Furthermore, optimization of their molecular design might increase the cytotoxic effect on tumors and...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Tianqi, Zhang, Jie, Oroujeni, Maryam, Tretyakova, Maria S., Bodenko, Vitalina, Belousov, Mikhail V., Orlova, Anna, Tolmachev, Vladimir, Vorobyeva, Anzhelika, Gräslund, Torbjörn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949183/
https://www.ncbi.nlm.nih.gov/pubmed/35335898
http://dx.doi.org/10.3390/pharmaceutics14030522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949183/
https://www.ncbi.nlm.nih.gov/pubmed/35335898
http://dx.doi.org/10.3390/pharmaceutics14030522

Ejemplares similares