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Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2

Targeted drug conjugates based on Affibody molecules fused to an albumin-binding domain (ABD) for half-life extension have demonstrated potent anti-tumor activity in preclinical therapeutic studies. Furthermore, optimization of their molecular design might increase the cytotoxic effect on tumors and...

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Detalles Bibliográficos
Autores principales:	Xu, Tianqi, Zhang, Jie, Oroujeni, Maryam, Tretyakova, Maria S., Bodenko, Vitalina, Belousov, Mikhail V., Orlova, Anna, Tolmachev, Vladimir, Vorobyeva, Anzhelika, Gräslund, Torbjörn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949183/ https://www.ncbi.nlm.nih.gov/pubmed/35335898 http://dx.doi.org/10.3390/pharmaceutics14030522

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