Study of Structure–Activity Relationships of the Marine Alkaloid Fascaplysin and Its Derivatives as Potent Anticancer Agents

Marine alkaloid fascaplysin and its derivatives are known to exhibit promising anticancer properties in vitro and in vivo. However, toxicity of these molecules to non-cancer cells was identified as a main limitation for their clinical use. Here, for the very first time, we synthesized a library of f...

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Detalles Bibliográficos
Autores principales: Zhidkov, Maxim E., Kaune, Moritz, Kantemirov, Alexey V., Smirnova, Polina A., Spirin, Pavel V., Sidorova, Maria A., Stadnik, Sergey A., Shyrokova, Elena Y., Kaluzhny, Dmitry N., Tryapkin, Oleg A., Busenbender, Tobias, Hauschild, Jessica, Rohlfing, Tina, Prassolov, Vladimir S., Bokemeyer, Carsten, Graefen, Markus, von Amsberg, Gunhild, Dyshlovoy, Sergey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949187/
https://www.ncbi.nlm.nih.gov/pubmed/35323484
http://dx.doi.org/10.3390/md20030185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949187/
https://www.ncbi.nlm.nih.gov/pubmed/35323484
http://dx.doi.org/10.3390/md20030185

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