Using ELP Repeats as a Scaffold for De Novo Construction of Gadolinium-Binding Domains within Multifunctional Recombinant Proteins for Targeted Delivery of Gadolinium to Tumour Cells

Three artificial proteins that bind the gadolinium ion (Gd(3+)) with tumour-specific ligands were de novo engineered and tested as candidate drugs for binary radiotherapy (BRT) and contrast agents for magnetic resonance imaging (MRI). Gd(3+)-binding modules were derived from calmodulin. They were jo...

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Detalles Bibliográficos
Autores principales: Pozdniakova, Natalia V., Ryabaya, Oxana V., Semkina, Alevtina S., Skribitsky, Vsevolod A., Shevelev, Alexei B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949254/
https://www.ncbi.nlm.nih.gov/pubmed/35328725
http://dx.doi.org/10.3390/ijms23063297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949254/
https://www.ncbi.nlm.nih.gov/pubmed/35328725
http://dx.doi.org/10.3390/ijms23063297

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