Cargando…

The miRNA-21-5p Payload in Exosomes from M2 Macrophages Drives Tumor Cell Aggression via PTEN/Akt Signaling in Renal Cell Carcinoma

M2 macrophages in the tumor microenvironment are important drivers of cancer metastasis. Exosomes play a critical role in the crosstalk between different cells by delivering microRNAs or other cargos. Whether exosomes derived from pro-tumorigenic M2 macrophages (M2-Exos) could modulate the metastati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Zhicheng, Hu, Junhui, Ishihara, Moe, Sharrow, Allison C., Flora, Kailey, He, Yao, Wu, Lily
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949275/ https://www.ncbi.nlm.nih.gov/pubmed/35328425 http://dx.doi.org/10.3390/ijms23063005

Ejemplares similares

Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway
por: Cao, Wenpeng, et al.
Publicado: (2021)

Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells
por: Zhang, S., et al.
Publicado: (2017)

MiR-21 promotes pterygium cell proliferation through the PTEN/AKT pathway
por: Li, Xia, et al.
Publicado: (2018)

Ischemic Postconditioning-Mediated miRNA-21 Protects against Cardiac ischemia/reperfusion Injury via PTEN/Akt Pathway
por: Tu, Yingfeng, et al.
Publicado: (2013)

Effects of miR-21 on proliferation and apoptosis of WT cells via PTEN/Akt pathway
por: Zhang, Xiuli, et al.
Publicado: (2020)

Circulating exosomal miR-21 mediates HUVEC proliferation and migration through PTEN/PI3K/AKT in Crohn’s disease
por: Xie, Xiaoran, et al.
Publicado: (2022)

Ursolic Acid Attenuates Diabetic Mesangial Cell Injury through the Up-Regulation of Autophagy via miRNA-21/PTEN/Akt/mTOR Suppression
por: Lu, Xinxing, et al.
Publicado: (2015)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

miR-21 Promotes Human Nucleus Pulposus Cell Proliferation through PTEN/AKT Signaling
por: Liu, Hongzhe, et al.
Publicado: (2014)

MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway
por: Luo, Mao, et al.
Publicado: (2017)

Huygens: science, payload and mission
por: Wilson, A
Publicado: (1997)

Satellite communications payload and system
por: Braun, T M
Publicado: (2012)

Cancer-Associated Fibroblasts Confer Gemcitabine Resistance to Pancreatic Cancer Cells through PTEN-Targeting miRNAs in Exosomes
por: Richards, Katherine E., et al.
Publicado: (2022)

Payload Delivery: Engineering Immune Cells to Disrupt the Tumour Microenvironment
por: Fowler, Daniel, et al.
Publicado: (2021)

Anticancer effect of curcumin inhibits cell growth through miR-21/PTEN/Akt pathway in breast cancer cell
por: Wang, Xinzheng, et al.
Publicado: (2017)

In vivo fermentation production of humanized noncoding RNAs carrying payload miRNAs for targeted anticancer therapy
por: Li, Peng-Cheng, et al.
Publicado: (2021)

hPMSCs-Derived Exosomal miRNA-21 Protects Against Aging-Related Oxidative Damage of CD4(+) T Cells by Targeting the PTEN/PI3K-Nrf2 Axis
por: Xiong, Yanlian, et al.
Publicado: (2021)

A Cubesat Payload for Exoplanet Detection
por: Iuzzolino, Marcella, et al.
Publicado: (2017)

MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway
por: He, Changjun, et al.
Publicado: (2015)

Matrine inhibits TPC-1 human thyroid cancer cells via the miR-21/PTEN/Akt pathway
por: Zhao, Lina, et al.
Publicado: (2018)

Targeting MicroRNA-21 Suppresses Gastric Cancer Cell Proliferation and Migration via PTEN/Akt Signaling Axis
por: Zhou, Hao, et al.
Publicado: (2019)

靶向抑制miRNA-21对K562细胞增殖及PTEN-PI3K/AKT通路的影响
Publicado: (2016)

Targeted Cell-to-Cell Delivery of Protein Payloads via the Granzyme-Perforin Pathway
por: Woodsworth, Daniel J., et al.
Publicado: (2017)

Bone marrow mesenchymal stem cell-derived exosomal miR-21 protects C-kit(+) cardiac stem cells from oxidative injury through the PTEN/PI3K/Akt axis
por: Shi, Bei, et al.
Publicado: (2018)

miRNA-21 inhibition inhibits osteosarcoma cell proliferation by targeting PTEN and regulating the TGF-β1 signaling pathway
por: Hu, Xiaoming, et al.
Publicado: (2018)

Exosomal miR-92b-3p Promotes Chemoresistance of Small Cell Lung Cancer Through the PTEN/AKT Pathway
por: Li, Ming, et al.
Publicado: (2021)

miRNA-21 promotes osteogenesis via the PTEN/PI3K/Akt/HIF-1α pathway and enhances bone regeneration in critical size defects
por: Yang, Chi, et al.
Publicado: (2019)

Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys
por: Zhao, Sheng, et al.
Publicado: (2021)

Establishment of xenografts of urological cancers on chicken chorioallantoic membrane (CAM) to study metastasis
por: Hu, Junhui, et al.
Publicado: (2019)

miRNA-21 inhibition suppresses the human epithelial ovarian cancer by targeting PTEN signal pathway
por: Hao, Baozhen, et al.
Publicado: (2019)

Payload for Contact Inspection Tasks with UAV Systems
por: González-deSantos, L. M., et al.
Publicado: (2019)

Antibody–drug conjugates: Recent advances in payloads
por: Wang, Zhijia, et al.
Publicado: (2023)

Mesenchymal stem cell-derived exosomes ameliorate cardiomyocyte apoptosis in hypoxic conditions through microRNA144 by targeting the PTEN/AKT pathway
por: Wen, Zhuzhi, et al.
Publicado: (2020)

Exosomal miR-21 regulates the TETs/PTENp1/PTEN pathway to promote hepatocellular carcinoma growth
por: Cao, Liang-qi, et al.
Publicado: (2019)

MiRNA-132 regulates the development of osteoarthritis in correlation with the modulation of PTEN/PI3K/AKT signaling
por: Zhang, Wei, et al.
Publicado: (2021)

Cooperative miRNA-dependent PTEN regulation drives resistance to BTK inhibition in B-cell lymphoid malignancies
por: Kapoor, Isha, et al.
Publicado: (2021)

Silencing miRNA-1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway
por: Wang, Lei, et al.
Publicado: (2021)

PTEN and AKT1 Variations in Childhood T-Cell Acute Lymphoblastic Leukemia
por: Küçükcankurt, Fulya, et al.
Publicado: (2020)

M2 Macrophages-Derived Exosomal miRNA-23a-3p Promotes the Progression of Oral Squamous Cell Carcinoma by Targeting PTEN
por: Li, Jun, et al.
Publicado: (2023)

Exosomes Derived from Adipose Mesenchymal Stem Cells Carrying miRNA-22-3p Promote Schwann Cells Proliferation and Migration through Downregulation of PTEN
por: Yang, Jianqiang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tik77ngm8vn7r31ekg26p5mvp3