Aggregates Associated with Instability of Antibodies during Aerosolization Induce Adverse Immunological Effects

Background: Immunogenicity refers to the inherent ability of a molecule to stimulate an immune response. Aggregates are one of the major risk factors for the undesired immunogenicity of therapeutic antibodies (Ab) and may ultimately result in immune-mediated adverse effects. For Ab delivered by inha...

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Detalles Bibliográficos
Autores principales: Sécher, Thomas, Bodier-Montagutelli, Elsa, Parent, Christelle, Bouvart, Laura, Cortes, Mélanie, Ferreira, Marion, MacLoughlin, Ronan, Ilango, Guy, Schmid, Otmar, Respaud, Renaud, Heuzé-Vourc’h, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949695/
https://www.ncbi.nlm.nih.gov/pubmed/35336045
http://dx.doi.org/10.3390/pharmaceutics14030671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949695/
https://www.ncbi.nlm.nih.gov/pubmed/35336045
http://dx.doi.org/10.3390/pharmaceutics14030671

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