Combining Carbon-Ion Irradiation and PARP Inhibitor, Olaparib Efficiently Kills BRCA1-Mutated Triple-Negative Breast Cancer Cells

BACKGROUND: Triple-negative breast cancer (TNBC) exhibits poor prognosis due to the lack of targets for hormonal or antibody-based therapies, thereby leading to limited success in the treatment of this cancer subtype. Poly (ADP-ribose) polymerase 1 (PARP1) is a critical factor for DNA repair, and us...

Descripción completa

Detalles Bibliográficos
Autores principales: Kawanishi, Miki, Fujita, Mayumi, Karasawa, Kumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950024/
https://www.ncbi.nlm.nih.gov/pubmed/35340889
http://dx.doi.org/10.1177/11782234221080553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950024/
https://www.ncbi.nlm.nih.gov/pubmed/35340889
http://dx.doi.org/10.1177/11782234221080553

Ejemplares similares