Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [(18)F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain

The degree of acetylation of lysine residues on histones influences the accessibility of DNA and, furthermore, the gene expression. Histone deacetylases (HDACs) are overexpressed in various tumour diseases, resulting in the interest in HDAC inhibitors for cancer therapy. The aim of this work is the...

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Detalles Bibliográficos
Autores principales: Clauß, Oliver, Schäker-Hübner, Linda, Wenzel, Barbara, Toussaint, Magali, Deuther-Conrad, Winnie, Gündel, Daniel, Teodoro, Rodrigo, Dukić-Stefanović, Sladjana, Ludwig, Friedrich-Alexander, Kopka, Klaus, Brust, Peter, Hansen, Finn K., Scheunemann, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950173/
https://www.ncbi.nlm.nih.gov/pubmed/35337122
http://dx.doi.org/10.3390/ph15030324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950173/
https://www.ncbi.nlm.nih.gov/pubmed/35337122
http://dx.doi.org/10.3390/ph15030324

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