PLA(2)-Triggered Activation of Cyclosporine-Phospholipid Prodrug as a Drug Targeting Approach in Inflammatory Bowel Disease Therapy

Oral medication with activity specifically at the inflamed sites throughout the gastrointestinal tract and limited systemic exposure would be a major advance in our therapeutic approach to inflammatory bowel disease (IBD). For this purpose, we have designed a prodrug by linking active drug moiety to...

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Detalles Bibliográficos
Autores principales: Markovic, Milica, Ben-Shabat, Shimon, Nagendra Manda, Jagadeesh, Abramov-Harpaz, Karina, Regev, Clil, Miller, Yifat, Aponick, Aaron, Zimmermann, Ellen M., Dahan, Arik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950246/
https://www.ncbi.nlm.nih.gov/pubmed/35336048
http://dx.doi.org/10.3390/pharmaceutics14030675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950246/
https://www.ncbi.nlm.nih.gov/pubmed/35336048
http://dx.doi.org/10.3390/pharmaceutics14030675

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