Discovery of a New Drug-like Series of OGT Inhibitors by Virtual Screening

O-GlcNAcylation is an essential post-translational modification installed by the enzyme O-β-N-acetyl-d-glucosaminyl transferase (OGT). Modulating this enzyme would be extremely valuable to better understand its role in the development of serious human pathologies, such as diabetes and cancer. Howeve...

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Detalles Bibliográficos
Autores principales: Loi, Elena M., Tomašič, Tihomir, Balsollier, Cyril, van Eekelen, Kevin, Weiss, Matjaž, Gobec, Martina, Alteen, Matthew G., Vocadlo, David J., Pieters, Roland J., Anderluh, Marko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950328/
https://www.ncbi.nlm.nih.gov/pubmed/35335358
http://dx.doi.org/10.3390/molecules27061996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950328/
https://www.ncbi.nlm.nih.gov/pubmed/35335358
http://dx.doi.org/10.3390/molecules27061996

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