A Computational Understanding of Inter-Individual Variability in CYP2D6 Activity to Investigate the Impact of Missense Mutations on Ochratoxin A Metabolism

Cytochrome P-450 (CYP) enzymes have a key role in the metabolism of xenobiotics of food origin, and their highly polymorphic nature concurs with the diverse inter-individual variability in the toxicokinetics (TK) and toxicodynamics (TD) of food chemicals. Ochratoxin A is a well-known mycotoxin which...

Descripción completa

Detalles Bibliográficos
Autores principales: Dorne, Jean Lou C. M., Cirlini, Martina, Louisse, Jochem, Pedroni, Lorenzo, Galaverna, Gianni, Dellafiora, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950366/
https://www.ncbi.nlm.nih.gov/pubmed/35324704
http://dx.doi.org/10.3390/toxins14030207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950366/
https://www.ncbi.nlm.nih.gov/pubmed/35324704
http://dx.doi.org/10.3390/toxins14030207

Ejemplares similares