Cargando…

A Computational Understanding of Inter-Individual Variability in CYP2D6 Activity to Investigate the Impact of Missense Mutations on Ochratoxin A Metabolism

Cytochrome P-450 (CYP) enzymes have a key role in the metabolism of xenobiotics of food origin, and their highly polymorphic nature concurs with the diverse inter-individual variability in the toxicokinetics (TK) and toxicodynamics (TD) of food chemicals. Ochratoxin A is a well-known mycotoxin which...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dorne, Jean Lou C. M., Cirlini, Martina, Louisse, Jochem, Pedroni, Lorenzo, Galaverna, Gianni, Dellafiora, Luca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950366/ https://www.ncbi.nlm.nih.gov/pubmed/35324704 http://dx.doi.org/10.3390/toxins14030207

Ejemplares similares

A Computational Inter-Species Study on Safrole Phase I Metabolism-Dependent Bioactivation: A Mechanistic Insight into the Study of Possible Differences among Species
por: Pedroni, Lorenzo, et al.
Publicado: (2023)

In silico study on the Hepatitis E virus RNA Helicase and its inhibition by silvestrol, rocaglamide and other flavagline compounds
por: Pedroni, Lorenzo, et al.
Publicado: (2022)

An In Silico Framework to Mine Bioactive Peptides from Annotated Proteomes: A Case Study on Pancreatic Alpha Amylase Inhibitory Peptides from Algae and Cyanobacteria
por: Pedroni, Lorenzo, et al.
Publicado: (2022)

An In Silico Target Fishing Approach to Identify Novel Ochratoxin A Hydrolyzing Enzyme
por: Dellafiora, Luca, et al.
Publicado: (2020)

A Structural Study on the Listeria Monocytogenes Internalin A—Human E-cadherin Interaction: A Molecular Tool to Investigate the Effects of Missense Mutations
por: Dellafiora, Luca, et al.
Publicado: (2020)

Toxicodynamics of Mycotoxins in the Framework of Food Risk Assessment—An In Silico Perspective
por: Dellafiora, Luca, et al.
Publicado: (2018)

Mechanistic Insights into Angiotensin I-Converting Enzyme Inhibitory Tripeptides to Decipher the Chemical Basis of Their Activity
por: Lammi, Carmen, et al.
Publicado: (2022)

Degradation of Aflatoxins by Means of Laccases from Trametes versicolor: An In Silico Insight
por: Dellafiora, Luca, et al.
Publicado: (2017)

Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)
por: Louisse, Jochem, et al.
Publicado: (2022)

On the Mechanism of Action of Anti-Inflammatory Activity of Hypericin: An In Silico Study Pointing to the Relevance of Janus Kinases Inhibition
por: Dellafiora, Luca, et al.
Publicado: (2018)

Sprouts of Moringa oleifera Lam.: Germination, Polyphenol Content and Antioxidant Activity
por: Cirlini, Martina, et al.
Publicado: (2022)

Untargeted Metabolomics of Meat Digests: Its Potential to Differentiate Pork Depending on the Feeding Regimen
por: Cirlini, Martina, et al.
Publicado: (2023)

Vegetable By-Product Lacto-Fermentation as a New Source of Antimicrobial Compounds
por: Ricci, Annalisa, et al.
Publicado: (2019)

“Bottom-Up” Strategy for the Identification of Novel Soybean Peptides with Angiotensin-Converting Enzyme Inhibitory Activity
por: Dellafiora, Luca, et al.
Publicado: (2020)

Use of Dairy and Plant-Derived Lactobacilli as Starters for Cherry Juice Fermentation
por: Ricci, Annalisa, et al.
Publicado: (2019)

The Influence of Viable Cells and Cell-Free Extracts of Lactobacillus casei on Volatile Compounds and Polyphenolic Profile of Elderberry Juice
por: Ricci, Annalisa, et al.
Publicado: (2018)

In Silico Approaches Applied to the Study of Peptide Analogs of Ile-Pro-Ile in Relation to Their Dipeptidyl Peptidase IV Inhibitory Properties
por: Nongonierma, Alice B., et al.
Publicado: (2018)

Co-Occurrence and Combinatory Effects of Alternaria Mycotoxins and Other Xenobiotics of Food Origin: Current Scenario and Future Perspectives
por: Crudo, Francesco, et al.
Publicado: (2019)

Thinking Out of the Box: On the Ability of Zea mays L. to Biotrasform Aflatoxin B1 Into Its Modified Forms
por: Righetti, Laura, et al.
Publicado: (2021)

Understanding Inter-Individual Variability in Monoclonal Antibody Disposition
por: Thomas, Veena A., et al.
Publicado: (2019)

Alternaria toxins as casein kinase 2 inhibitors and possible consequences for estrogenicity: a hybrid in silico/in vitro study
por: Aichinger, Georg, et al.
Publicado: (2020)

Durum Wheat (Triticum Durum Desf.) Lines Show Different Abilities to Form Masked Mycotoxins under Greenhouse Conditions
por: Cirlini, Martina, et al.
Publicado: (2013)

Perenniality, more than genotypes, shapes biological and chemical rhizosphere composition of perennial wheat lines
por: Bertola, Marta, et al.
Publicado: (2023)

Open Field Study of Some Zea mays Hybrids, Lipid Compounds and Fumonisins Accumulation
por: Giorni, Paola, et al.
Publicado: (2015)

Study on inter-ethnic human differences in bioactivation and detoxification of estragole using physiologically based kinetic modeling
por: Ning, Jia, et al.
Publicado: (2017)

Understanding inter-individual variability in pharmacokinetics/pharmacodynamics of aripiprazole in children with tic disorders: Individualized administration based on physiological development and CYP2D6 genotypes
por: Xin, Yingying, et al.
Publicado: (2022)

Simulated Gastrointestinal Digestion of Cocoa: Detection of Resistant Peptides and In Silico/In Vitro Prediction of Their Ace Inhibitory Activity
por: Marseglia, Angela, et al.
Publicado: (2019)

Inter-individual Variability of Coumarin 7-hydroxylation (CYP2A6 activity) in an Iranian Population
por: Hassanzadeh Khayyat, Mohammad, et al.
Publicado: (2013)

COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine
por: Pereira, Naveen L., et al.
Publicado: (2021)

Effects of Ochratoxin A on Livestock Production
por: Battacone, Gianni, et al.
Publicado: (2010)

Assessment of the Multifunctional Behavior of Lupin Peptide P7 and Its Metabolite Using an Integrated Strategy
por: Lammi, Carmen, et al.
Publicado: (2020)

Cyclodextrins Can Entrap Zearalenone-14-Glucoside: Interaction of the Masked Mycotoxin with Cyclodextrins and Cyclodextrin Bead Polymer
por: Faisal, Zelma, et al.
Publicado: (2019)

Toolbox for the Extraction and Quantification of Ochratoxin A and Ochratoxin Alpha Applicable for Different Pig and Poultry Matrices
por: Streit, Barbara, et al.
Publicado: (2022)

MutaCYP: Classification of missense mutations in human cytochromes P450
por: Fechter, Kenneth, et al.
Publicado: (2014)

Impact of a Shorter Brine Soaking Time on Nutrient Bioaccessibility and Peptide Formation in 30-Months-Ripened Parmigiano Reggiano Cheese
por: Di Nunzio, Mattia, et al.
Publicado: (2022)

LDS1-produced oxylipins are negative regulators of growth, conidiation and fumonisin synthesis in the fungal maize pathogen Fusarium verticillioides
por: Scala, Valeria, et al.
Publicado: (2014)

Cleaning the Label of Cured Meat; Effect of the Replacement of Nitrates/Nitrites on Nutrients Bioaccessibility, Peptides Formation, and Cellular Toxicity of In Vitro Digested Salami
por: Di Nunzio, Mattia, et al.
Publicado: (2022)

CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants
por: Zhang, Lingxin, et al.
Publicado: (2020)

Inter-Individual Variability and Conspecific Densities: Consequences for Population Regulation and Range Expansion
por: Cardador, Laura, et al.
Publicado: (2012)

Inter occasion variability in individual optimal design
por: Kristoffersson, Anders N., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_5t8he5em493n344dbe378vhs66