Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity

The spike proteins of enveloped viruses are transmembrane glycoproteins that typically undergo post-translational attachment of palmitate on cysteine residues on the cytoplasmic facing tail of the protein. The role of spike protein palmitoylation in virus biogenesis and infectivity is being actively...

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Detalles Bibliográficos
Autores principales: Ramadan, Ahmed A., Mayilsamy, Karthick, McGill, Andrew R., Ghosh, Anandita, Giulianotti, Marc A., Donow, Haley M., Mohapatra, Shyam S., Mohapatra, Subhra, Chandran, Bala, Deschenes, Robert J., Roy, Arunava
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950683/
https://www.ncbi.nlm.nih.gov/pubmed/35336938
http://dx.doi.org/10.3390/v14030531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950683/
https://www.ncbi.nlm.nih.gov/pubmed/35336938
http://dx.doi.org/10.3390/v14030531

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