Processing Parameters and Ion Excipients Affect the Physicochemical Characteristics of the Stereocomplex-Formed Polylactide-b-Polyethylene Glycol Nanoparticles and Their Pharmacokinetics

To optimize the characteristics of stereocomplex polylactide-b-polyethylene glycol nanoparticles (SC-PEG NPs) in terms of pharmacokinetics (PK), we chose continuous anti-solvent precipitation with a T-junction as a preparation method and investigated the effect of using solvents containing an ion ex...

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Detalles Bibliográficos
Autores principales: Ogawa, Kohei, Katsumi, Hidemasa, Moroto, Yasushi, Morishita, Masaki, Yamamoto, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950890/
https://www.ncbi.nlm.nih.gov/pubmed/35335944
http://dx.doi.org/10.3390/pharmaceutics14030568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950890/
https://www.ncbi.nlm.nih.gov/pubmed/35335944
http://dx.doi.org/10.3390/pharmaceutics14030568

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