Computational Design and Biological Evaluation of Analogs of Lupin Peptide P5 Endowed with Dual PCSK9/HMG-CoAR Inhibiting Activity

(1) Background: Proprotein convertase subtilisin/kexin 9 (PCSK9) is responsible for the degradation of the hepatic low-density lipoprotein receptor (LDLR), which regulates the circulating cholesterol level. In this field, we discovered natural peptides derived from lupin that showed PCSK9 inhibitory...

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Detalles Bibliográficos
Autores principales: Lammi, Carmen, Fassi, Enrico M. A., Li, Jianqiang, Bartolomei, Martina, Benigno, Giulia, Roda, Gabriella, Arnoldi, Anna, Grazioso, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951016/
https://www.ncbi.nlm.nih.gov/pubmed/35336039
http://dx.doi.org/10.3390/pharmaceutics14030665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951016/
https://www.ncbi.nlm.nih.gov/pubmed/35336039
http://dx.doi.org/10.3390/pharmaceutics14030665

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