Design, Synthesis and Biological Activity Testing of Library of Sphk1 Inhibitors

Our team discovered a moderate SphK1 inhibitor, SAMS10 (IC(50) = 9.8 μM), which was screened by computer-assisted screening. In this study, we developed a series of novel diaryl derivatives with improved antiproliferative activities by modifying the structure of the lead compound SAMS10. A total of...

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Detalles Bibliográficos
Autores principales: Geng, Shuangshuang, Chen, Haijiao, Li, Yan, Li, Ying, Pang, Jingxiang, Zhang, Feipeng, Qu, Zhiqiang, Li, Mengjun, Liu, Na, Yao, Qingqiang, Mu, Yanling, Liu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951126/
https://www.ncbi.nlm.nih.gov/pubmed/35335379
http://dx.doi.org/10.3390/molecules27062020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951126/
https://www.ncbi.nlm.nih.gov/pubmed/35335379
http://dx.doi.org/10.3390/molecules27062020

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