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Design, Synthesis and Biological Activity Testing of Library of Sphk1 Inhibitors
Our team discovered a moderate SphK1 inhibitor, SAMS10 (IC(50) = 9.8 μM), which was screened by computer-assisted screening. In this study, we developed a series of novel diaryl derivatives with improved antiproliferative activities by modifying the structure of the lead compound SAMS10. A total of...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951126/ https://www.ncbi.nlm.nih.gov/pubmed/35335379 http://dx.doi.org/10.3390/molecules27062020 |