Development and Validation of the New Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Unbound Tacrolimus in the Plasma Ultrafiltrate of Transplant Recipients

(1) Background: Only unbound tacrolimus particles are considered to be active and capable of crossing cellular membranes. Thus, the free-drug concentration might be better associated with clinical effects than the total drug concentration used for dosage adjustment. We propose a new, fully validated...

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Detalles Bibliográficos
Autores principales: Bodnar-Broniarczyk, Magdalena, Warzyszyńska, Karola, Czerwińska, Katarzyna, Marszałek, Dorota, Dziewa, Natalia, Kosieradzki, Maciej, Pawiński, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951301/
https://www.ncbi.nlm.nih.gov/pubmed/35336007
http://dx.doi.org/10.3390/pharmaceutics14030632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951301/
https://www.ncbi.nlm.nih.gov/pubmed/35336007
http://dx.doi.org/10.3390/pharmaceutics14030632

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