In Silico and In Vitro Identification of Pan-Coronaviral Main Protease Inhibitors from a Large Natural Product Library

The main protease (M(pro) or 3CL(pro)) in coronaviruses represents a promising specific drug target as it is essential for the cleavage of the virus polypeptide and has a unique cleavage site that does not exist in human host proteases. In this study, we explored potential natural pan-coronavirus dr...

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Detalles Bibliográficos
Autores principales: Shahhamzehei, Nasim, Abdelfatah, Sara, Efferth, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952009/
https://www.ncbi.nlm.nih.gov/pubmed/35337106
http://dx.doi.org/10.3390/ph15030308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952009/
https://www.ncbi.nlm.nih.gov/pubmed/35337106
http://dx.doi.org/10.3390/ph15030308

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