Cargando…

Synthesis, Antiplasmodial, and Antileukemia Activity of Dihydroartemisinin–HDAC Inhibitor Hybrids as Multitarget Drugs

Artemisinin-based combination therapies (ACTs) are the gold standard for the treatment of malaria, but the efficacy is threatened by the development of parasite resistance. Histone deacetylase inhibitors (HDACis) are an emerging new class of potential antiplasmodial drugs. In this work, we present t...

Descripción completa

Detalles Bibliográficos
Autores principales:	von Bredow, Lukas, Schäfer, Thomas Martin, Hogenkamp, Julian, Tretbar, Maik, Stopper, Daniel, Kraft, Fabian B., Schliehe-Diecks, Julian, Schöler, Andrea, Borkhardt, Arndt, Bhatia, Sanil, Held, Jana, Hansen, Finn K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952208/ https://www.ncbi.nlm.nih.gov/pubmed/35337131 http://dx.doi.org/10.3390/ph15030333

Ejemplares similares

Oxa Analogues of Nexturastat A Demonstrate Improved HDAC6 Selectivity and Superior Antileukaemia Activity
por: Pflieger, Marc, et al.
Publicado: (2021)

Borinostats: solid-phase synthesis of carborane-capped histone deacetylase inhibitors with a tailor-made selectivity profile
por: Selg, Christoph, et al.
Publicado: (2021)

Development of the first geldanamycin-based HSP90 degraders
por: Wurnig, Silas, et al.
Publicado: (2023)

Hydroxamic Acids Immobilized on Resins (HAIRs): Synthesis of Dual‐Targeting HDAC Inhibitors and HDAC Degraders (PROTACs)
por: Sinatra, Laura, et al.
Publicado: (2020)

Metformin exerts multitarget antileukemia activity in JAK2(V617F)-positive myeloproliferative neoplasms
por: Machado-Neto, João Agostinho, et al.
Publicado: (2018)

Repurposing immunosuppressants for antileukemia therapy
por: Sezaki, Maiko, et al.
Publicado: (2022)

Walk the line—dispersal movements of gray mouse lemurs (Microcebus murinus)
por: Schliehe-Diecks, Susanne, et al.
Publicado: (2012)

Exploration of thiaheterocyclic hHDAC6 inhibitors as potential antiplasmodial agents
por: Vreese, Rob De, et al.
Publicado: (2017)

Interleukin-2-Inducible T-Cell Kinase Deficiency—New Patients, New Insight?
por: Ghosh, Sujal, et al.
Publicado: (2018)

Corrigendum: Interleukin-2-Inducible T-Cell Kinase Deficiency—New Patients, New Insight?
por: Ghosh, Sujal, et al.
Publicado: (2018)

Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization
por: Bhatia, Sanil, et al.
Publicado: (2022)

Synthesis and Antileukemia Activity Evaluation of Benzophenanthridine Alkaloid Derivatives
por: Tang, Yaling, et al.
Publicado: (2022)

Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes
por: Di Pietro, Maria Letizia, et al.
Publicado: (2022)

The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism
por: Stuhldreier, Fabian, et al.
Publicado: (2022)

Formulation, antileukemia mechanism, pharmacokinetics, and biodistribution of a novel liposomal emodin
por: Wang, Tiechuang, et al.
Publicado: (2012)

Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects
por: Ureshino, Hiroshi, et al.
Publicado: (2021)

Senescent Tumor CD8(+) T Cells: Mechanisms of Induction and Challenges to Immunotherapy
por: Liu, Wei, et al.
Publicado: (2020)

Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents
por: Beus, Maja, et al.
Publicado: (2019)

Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite
por: Ricciardi, M. R., et al.
Publicado: (2017)

Modeling the Antileukemia Activity of Ellipticine-Related Compounds: QSAR and Molecular Docking Study
por: Márquez, Edgar, et al.
Publicado: (2019)

The Mycotoxin Beauvericin Exhibits Immunostimulatory Effects on Dendritic Cells via Activating the TLR4 Signaling Pathway
por: Yang, Xiaoli, et al.
Publicado: (2022)

Erratum to: Large-scale MHC class II genotyping of a wild lemur population by next generation sequencing
por: Huchard, Elise, et al.
Publicado: (2013)

Anticancer Activity of Natural and Semi-Synthetic Drimane and Coloratane Sesquiterpenoids
por: Beckmann, Lorenz, et al.
Publicado: (2022)

Synergizing Exchangeable Fluorophore Labels for Multitarget STED Microscopy
por: Glogger, Marius, et al.
Publicado: (2022)

Antiplasmodial Natural Products
por: Nogueira, Cláudio R., et al.
Publicado: (2011)

Large-scale MHC class II genotyping of a wild lemur population by next generation sequencing
por: Huchard, Elise, et al.
Publicado: (2012)

Design, synthesis and biological evaluation of VEGFR-2/HDAC dual inhibitors as multitargeted antitumor agents based on fruquintinib and vorinostat
por: Gao, Yali, et al.
Publicado: (2023)

Resistance to Dihydroartemisinin
por: Cojean, Sandrine, et al.
Publicado: (2006)

Resistance to Dihydroartemisinin
por: Legrand, Eric, et al.
Publicado: (2007)

Semi-Synthesis, Cytotoxic Evaluation, and Structure—Activity Relationships of Brefeldin A Derivatives with Antileukemia Activity
por: Lu, Xu-Xiu, et al.
Publicado: (2021)

Mechanisms of Dihydroartemisinin and Dihydroartemisinin/Holotransferrin Cytotoxicity in T-Cell Lymphoma Cells
por: Wang, Qiuyan, et al.
Publicado: (2015)

Balancing Histone Deacetylase (HDAC) Inhibition and Drug‐likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors
por: Schäker‐Hübner, Linda, et al.
Publicado: (2022)

In vitro antiplasmodial activity of cepharanthine
por: Desgrouas, Camille, et al.
Publicado: (2014)

Antiplasmodial natural products: an update
por: Tajuddeen, Nasir, et al.
Publicado: (2019)

Synthesis and Antiplasmodial Activity of Bisindolylcyclobutenediones
por: Lande, Duc Hoàng, et al.
Publicado: (2021)

miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways
por: Fang, Zhi Hong, et al.
Publicado: (2016)

Design, Synthesis, and In Vitro Evaluation of Benzofuro[3,2-c]Quinoline Derivatives as Potential Antileukemia Agents
por: Lin, Ying, et al.
Publicado: (2020)

Inhibition of ULK1 promotes the death of leukemia cell in an autophagy irrelevant manner and exerts the antileukemia effect
por: Yang, Wei, et al.
Publicado: (2021)

IMMU-19. HDAC INHIBITORS SENSITIZE MYC-AMPLIFIED MEDULLOBLASTOMA TO IMMUNOTHERAPY BY ACTIVATING THE NF-kB PATHWAYS
por: Marquardt, Viktoria, et al.
Publicado: (2020)

In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells
por: Zhou, Qianxiang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nnpobt1rh47hg6i4fj1v42k5lc