The absence of the autoimmune regulator gene (AIRE) impairs the three-dimensional structure of medullary thymic epithelial cell spheroids

BACKGROUND: Besides controlling the expression of peripheral tissue antigens, the autoimmune regulator (AIRE) gene also regulates the expression of adhesion genes in medullary thymic epithelial cells (mTECs), an essential process for mTEC-thymocyte interaction for triggering the negative selection i...

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Detalles Bibliográficos
Autores principales: Monteleone-Cassiano, Ana Carolina, Dernowsek, Janaina A., Mascarenhas, Romario S., Assis, Amanda Freire, Pitol, Dimitrius, Santos Moreira, Natalia Chermont, Sakamoto-Hojo, Elza Tiemi, Issa, João Paulo Mardegan, Donadi, Eduardo A., Passos, Geraldo Aleixo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952272/
https://www.ncbi.nlm.nih.gov/pubmed/35331137
http://dx.doi.org/10.1186/s12860-022-00414-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952272/
https://www.ncbi.nlm.nih.gov/pubmed/35331137
http://dx.doi.org/10.1186/s12860-022-00414-9

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