Cargando…

A Histone Deacetylase (HDAC) Inhibitor with Pleiotropic In Vitro Anti-Toxoplasma and Anti-Plasmodium Activities Controls Acute and Chronic Toxoplasma Infection in Mice

Toxoplasmosis is a highly prevalent human disease, and virulent strains of this parasite emerge from wild biotopes. Here, we report on the potential of a histone deacetylase (HDAC) inhibitor we previously synthesized, named JF363, to act in vitro against a large panel of Toxoplasma strains, as well...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jublot, Delphine, Cavaillès, Pierre, Kamche, Salima, Francisco, Denise, Fontinha, Diana, Prudêncio, Miguel, Guichou, Jean-Francois, Labesse, Gilles, Sereno, Denis, Loeuillet, Corinne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952293/ https://www.ncbi.nlm.nih.gov/pubmed/35328672 http://dx.doi.org/10.3390/ijms23063254

Ejemplares similares

A Tiny Change Makes a Big Difference in the Anti-Parasitic Activities of an HDAC Inhibitor
por: Loeuillet, Corinne, et al.
Publicado: (2019)

Toxoplasma Hypervirulence in the Rat Model Parallels Human Infection and Is Modulated by the Toxo1 Locus
por: Loeuillet, Corinne, et al.
Publicado: (2019)

Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity
por: Loeuillet, C., et al.
Publicado: (2018)

In vitro and in vivo anti−Toxoplasma activities of HDAC inhibitor Panobinostat on experimental acute ocular toxoplasmosis
por: Zhang, Yu, et al.
Publicado: (2022)

In vivo anti-Toxoplasma activity of aripiprazole
por: Saraei, Mehrzad, et al.
Publicado: (2015)

Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis
por: Ghazy, Ehab, et al.
Publicado: (2022)

HDAC inhibitors Tubastatin A and SAHA affect parasite cell division and are potential anti-Toxoplasma gondii chemotherapeutics
por: Araujo-Silva, Carlla Assis, et al.
Publicado: (2020)

Nano DNA Vaccine Encoding Toxoplasma gondii Histone Deacetylase SIR2 Enhanced Protective Immunity in Mice
por: Yu, Zhengqing, et al.
Publicado: (2021)

TgKDAC4: A Unique Deacetylase of Toxoplasma’s Apicoplast
por: Fragoso, Mariana Sayuri Ishikawa, et al.
Publicado: (2023)

The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs
por: Vaca, Hugo Rolando, et al.
Publicado: (2021)

Investigation of Anti-Toxocara and Anti-Toxoplasma Antibodies in Patients with Schizophrenia Disorder
por: Khademvatan, Shahram, et al.
Publicado: (2014)

High-content imaging assay to evaluate Toxoplasma gondii infection and proliferation: A multiparametric assay to screen new compounds
por: Touquet, Bastien, et al.
Publicado: (2018)

Histone Deacetylase Inhibitors, Intrinsic and Extrinsic Apoptotic Pathways, and Epigenetic Alterations of Histone Deacetylases (HDACs) in Hepatocellular Carcinoma
por: Sanaei, Masumeh, et al.
Publicado: (2021)

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases
por: Moreno-Yruela, Carlos, et al.
Publicado: (2022)

Expression of Histone Deacetylases HDAC1, HDAC2, HDAC3, and HDAC6 in Invasive Ductal Carcinomas of the Breast
por: Seo, Jinwon, et al.
Publicado: (2014)

Anti-Toxoplasma Effects of Dracocephalum Polychaetum Essential Oil
por: Khamesipour, Faham, et al.
Publicado: (2022)

In vitro and in vivo Anti-Toxoplasma Effects of Allium sativum Essential Oil Against Toxoplasma gondii RH Strain
por: Alnomasy, Sultan F
Publicado: (2021)

Transcription Regulation by Class III Histone Deacetylases (HDACs)—Sirtuins
por: Dai, Yan, et al.
Publicado: (2008)

Histone deacetylases (HDACs) in XPC gene silencing and bladder cancer
por: Xu, Xiaoxin S, et al.
Publicado: (2011)

The Role of Dietary Histone Deacetylases (HDACs) Inhibitors in Health and Disease
por: Bassett, Shalome A., et al.
Publicado: (2014)

Histone Deacetylases (HDACs) Guided Novel Therapies for T-cell lymphomas
por: Zhang, Qing, et al.
Publicado: (2019)

Histone Deacetylases (HDACs) and Atherosclerosis: A Mechanistic and Pharmacological Review
por: Chen, Xiaona, et al.
Publicado: (2020)

Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish
por: Moreira, Jôsimar D., et al.
Publicado: (2020)

CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2
por: Boucheron, Nicole, et al.
Publicado: (2014)

Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors
por: Galán, María, et al.
Publicado: (2016)

Serologic Detection of Anti Toxoplasma gondii Infection in Diabetic Patients
por: Shirbazou, Shahnaz, et al.
Publicado: (2013)

Seroprevalence of anti-Toxoplasma gondii antibodies in Egyptian sheep and goats
por: Al-Kappany, Yara M., et al.
Publicado: (2018)

Anti-Toxoplasma Activities of the Hydroalcoholic Extract of Some Brassicaceae Species
por: Montazeri, Mahbobeh, et al.
Publicado: (2020)

Anti-Toxoplasma activity of Sorghum bicolor-derived lipophilic fractions
por: Abugri, Daniel A., et al.
Publicado: (2019)

Promising Drug Targets and Compounds with Anti-Toxoplasma gondii Activity
por: da Silva, Marco, et al.
Publicado: (2021)

In vitro anti-Toxoplasma gondii efficacy of synthesised benzyltriazole derivatives
por: Guo, Huanping, et al.
Publicado: (2021)

Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo
por: Zhang, Run-Hui, et al.
Publicado: (2021)

The anti-Toxoplasma activity of the plant natural phenolic compound piceatannol
por: Jiang, Yucong, et al.
Publicado: (2022)

The In Vitro Anti-Parasitic Activities of Emodin toward Toxoplasma gondii
por: Adeyemi, Oluyomi Stephen, et al.
Publicado: (2023)

In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts
por: ahmadi, Mohammad, et al.
Publicado: (2023)

Anti-Toxoplasma gondii Effects of Lipopeptide Derivatives of Lycosin-I
por: Liu, Xiaohua, et al.
Publicado: (2023)

Sulfadiazine analogs: anti-Toxoplasma in vitro study of sulfonamide triazoles
por: Arafa, Fadwa M, et al.
Publicado: (2023)

Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity
por: Darwish, Salma, et al.
Publicado: (2022)

Histone deacetylase 9 regulates breast cancer cell proliferation and the response to histone deacetylase inhibitors
por: Lapierre, Marion, et al.
Publicado: (2016)

ROP18 Is a Rhoptry Kinase Controlling the Intracellular Proliferation of Toxoplasma gondii
por: El Hajj, Hiba, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_cmq11n0qcosr36c92pqe9uu2u0