Multiscale Model of Antiviral Timing, Potency, and Heterogeneity Effects on an Epithelial Tissue Patch Infected by SARS-CoV-2

We extend our established agent-based multiscale computational model of infection of lung tissue by SARS-CoV-2 to include pharmacokinetic and pharmacodynamic models of remdesivir. We model remdesivir treatment for COVID-19; however, our methods are general to other viral infections and antiviral the...

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Detalles Bibliográficos
Autores principales: Ferrari Gianlupi, Juliano, Mapder, Tarunendu, Sego, T. J., Sluka, James P., Quinney, Sara K., Craig, Morgan, Stratford, Robert E., Glazier, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953050/
https://www.ncbi.nlm.nih.gov/pubmed/35337012
http://dx.doi.org/10.3390/v14030605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953050/
https://www.ncbi.nlm.nih.gov/pubmed/35337012
http://dx.doi.org/10.3390/v14030605

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