Cargando…

MiR-183-5p Induced by Saturated Fatty Acids Hinders Insulin Signaling by Downregulating IRS-1 in Hepatocytes

Excessive saturated fatty acids (SFA) uptake is known to be a primary cause of obesity, a widely acknowledged risk factor of insulin resistance and type 2 diabetes. Although specific microRNAs (miRNAs) targeting insulin signaling intermediates are dysregulated by SFA, their effects on insulin signal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Mai Thi, Min, Kyung-Ho, Lee, Wan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953084/ https://www.ncbi.nlm.nih.gov/pubmed/35328400 http://dx.doi.org/10.3390/ijms23062979

Ejemplares similares

MiR-183-5p induced by saturated fatty acids regulates the myogenic differentiation by directly targeting FHL1 in C2C12 myoblasts
por: Nguyen, Mai Thi, et al.
Publicado: (2020)

Induction of miR-96 by Dietary Saturated Fatty Acids Exacerbates Hepatic Insulin Resistance through the Suppression of INSR and IRS-1
por: Yang, Won-Mo, et al.
Publicado: (2016)

Palmitic Acid-Induced miR-429-3p Impairs Myoblast Differentiation by Downregulating CFL2
por: Nguyen, Mai Thi, et al.
Publicado: (2021)

Saturated fatty acid-inducible miR-103-3p impairs the myogenic differentiation of progenitor cells by enhancing cell proliferation through Twinfilin-1/F-actin/YAP1 axis
por: Nguyen, Mai Thi, et al.
Publicado: (2023)

TNF-α Downregulation Modifies Insulin Receptor Substrate 1 (IRS-1) in Metabolic Signaling of Diabetic Insulin-Resistant Hepatocytes
por: Alipourfard, Iraj, et al.
Publicado: (2019)

Downregulation of miR-183 inhibits apoptosis and enhances the invasive potential of endometrial stromal cells in endometriosis
por: SHI, XIAO-YAN, et al.
Publicado: (2014)

miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells
por: ZHAO, HAIEN, et al.
Publicado: (2012)

Expression of miR-127, miR-154, and miR-183 in Medullary Thyroid Carcinoma Tumors
por: RAHMANI SAMANI, Mahsa, et al.
Publicado: (2021)

IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1(−/−) Mice Mediated by miR-33
por: Tang, Chen-Yi, et al.
Publicado: (2017)

Plasma miR-19b and miR-183 as Potential Biomarkers of Lung Cancer
por: Zaporozhchenko, Ivan A., et al.
Publicado: (2016)

miR-96 and miR-183 differentially regulate neonatal and adult postinfarct neovascularization
por: Castellan, Raphael F.P., et al.
Publicado: (2020)

LINC01140 Hinders the Development of Breast Cancer Through Targeting miR-200b-3p to Downregulate DMD
por: Peng, Gongling, et al.
Publicado: (2023)

Data on the expression and insulin-stimulated phosphorylation of IRS-1 by miR-96 in L6-GLUT4myc myocytes
por: Yang, Won-Mo, et al.
Publicado: (2017)

miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression
por: Benito-Vicente, Asier, et al.
Publicado: (2020)

Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance
por: Garcia-Martinez, Irma, et al.
Publicado: (2023)

miR-183 inhibits TGF-β1-induced apoptosis by downregulation of PDCD4 expression in human hepatocellular carcinoma cells
por: Li, Jipeng, et al.
Publicado: (2010)

Dysregulated miR-183 inhibits migration in breast cancer cells
por: Lowery, Aoife J, et al.
Publicado: (2010)

Melittin induces NSCLC apoptosis via inhibition of miR-183
por: Gao, Dongqi, et al.
Publicado: (2018)

Ablation of Mature miR-183 Leads to Retinal Dysfunction in Mice
por: Zhang, Chang-Jun, et al.
Publicado: (2020)

Somatic MIWI2 Hinders Direct Lineage Reprogramming From Fibroblast to Hepatocyte
por: Shi, Xiaojie, et al.
Publicado: (2019)

Modulation of Insulin Sensitivity of Hepatocytes by the Pharmacological Downregulation of Phospholipase D
por: Babenko, Nataliya A., et al.
Publicado: (2015)

miR-182 and miR-183 Promote Cell Proliferation and Invasion by Targeting FOXO1 in Mesothelioma
por: Suzuki, Rui, et al.
Publicado: (2018)

Clinical Significance of miR-183-3p and miR-182-5p in NSCLC and Their Correlation
por: Zhang, Tianxiang, et al.
Publicado: (2021)

MiR-711 and miR-183-3p as potential markers for vital reaction of burned skin
por: Zhang, Kaikai, et al.
Publicado: (2020)

Downregulation of miR-183 inhibits the growth of PANC-1 pancreatic cancer cells in vitro and in vivo, and increases chemosensitivity to 5-fluorouracil and gemcitabine
por: Yang, Xiaoping, et al.
Publicado: (2019)

Role of HO-1 against Saturated Fatty Acid-Induced Oxidative Stress in Hepatocytes
por: Ogino, Noriyoshi, et al.
Publicado: (2021)

Deficiency of CREB and over expression of miR-183 in juvenile myelomonocytic leukemia
por: Liu, Y L, et al.
Publicado: (2013)

MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma
por: Lodrini, Marco, et al.
Publicado: (2013)

Expression and Misexpression of the miR-183 Family in the Developing Hearing Organ of the Chicken
por: Zhang, Kaidi D., et al.
Publicado: (2015)

Deregulation of miR-183 and KIAA0101 in Aggressive and Malignant Pituitary Tumors
por: Roche, Magali, et al.
Publicado: (2015)

Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKβ and mTORC1
por: Denhez, Benoit, et al.
Publicado: (2020)

A mouse model of miR-96, miR-182 and miR-183 misexpression implicates miRNAs in cochlear cell fate and homeostasis
por: Weston, Michael D., et al.
Publicado: (2018)

Downregulated Circular RNA hsa_circ_0000291 Suppresses Migration And Proliferation Of Gastric Cancer Via Targeting The miR-183/ITGB1 Axis
por: Cao, Chuanwu, et al.
Publicado: (2019)

The Long Non-Coding RNA CASC2 Suppresses Cell Viability, Migration, and Invasion in Hepatocellular Carcinoma Cells by Directly Downregulating miR-183
por: Sun, Jian, et al.
Publicado: (2019)

The Induction of MicroRNA Targeting IRS-1 Is Involved in the Development of Insulin Resistance under Conditions of Mitochondrial Dysfunction in Hepatocytes
por: Ryu, Hyun Su, et al.
Publicado: (2011)

Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro
por: Wu, G, et al.
Publicado: (2011)

Data on the expression of PEPCK in HepG2 hepatocytes transfected with miR-195
por: Yang, Won-Mo, et al.
Publicado: (2017)

AdipoRon prevents myostatin‐induced upregulation of fatty acid synthesis and downregulation of insulin activity in a mouse hepatocyte line
por: Liu, Xin‐Hua, et al.
Publicado: (2019)

miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons
por: Roser, Anna-Elisa, et al.
Publicado: (2018)

miR-183 regulates autophagy and apoptosis in colorectal cancer through targeting of UVRAG
por: Huangfu, Longtao, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_4uo3uh4as90mheiiqf913sit81